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KMID : 0616120220530030138
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Korean Journal of Pharmacognosy
2022 Volume.53 No. 3 p.138 ~ p.144
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Effects of Betaone Extract on the Inhibition of Adipocyte Differentiation in High-fat Diet-induced Obesit
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Lee Yong-Jin
Shin Han-Byeol
Lee Mi-Ja
Lee Mi-Kyung
Son Young-Jin
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Abstract
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Obesity is a disease in which an abnormally large amount of fat accumulates in the body. Various diseases such as type 2 diabetes, dyslipidemia, high blood pressure, fatty liver, gallbladder disease, and coronary artery disease are induced. In this study, we investigated the effect of betaone, a type of barley, on obesity suppression. After the betaone extract was treated with 3T3 L1 adipocytes, the effect on adipocyte formation was investigated through Oil Red O staining. It was observed that differentiation was inhibited without affecting the viability of 3T3 L1 adipocytes. The effect of betaone extract on obesity inhibition in a mouse model was investigated. As a result of administering betaone extract after a high-fat diet, it was confirmed that the level of blood sugar and body weight was decreased, and glucose uptake ability was improved in a glucose tolerance test. The formation of mouse adipose tissue was suppressed, and the expression of genes involved in the formation and degradation of obesity in liver tissue was improved. These results suggest that betaone extract is a useful substance for improving obesity and is an excellent material for health functional food.
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KEYWORD
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Obesity, Barley extract, Adipocyte differentiation, High-fat, Glucose tolerance test
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